The principal cytochrome P450 isoenzyme involved seems to get CYP2E1, with CYP1A2 and CYP3A4 as supplemental pathways. About 85% of an oral dose appears inside the urine within just 24 hrs of administration, most given that the glucuronide conjugate, with small quantities of other conjugates and unchanged drug.The concomitant use of opioids with ot